منابع مشابه
Progress toward inducing immunologic tolerance to factor VIII.
A major problem in treating hemophilia A patients with therapeutic factor VIII (FVIII) is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies. These antibodies block (inhibit) the procoagulant function of FVIII and thus are termed "inhibitors." The currently accepted clinical method to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol re...
متن کاملTolerance: pregnancy matters.
progenitor cell functional assays were included in the studies by Calado et al. Although it is logical that increasing TERT activity would increase hematopoietic stem/progenitor cell function, no direct studies addressed this critical question. Understanding whether androgen/estradiol-induced TERT activation also occurs in hematopoietic stem/progenitors is crucial because it is loss of these ce...
متن کاملQuinine Tolerance in Pregnancy
Sir,?The above article in the December 1937 issue interested me very much because it raises some other points. The patient was given nine 10-grain quinine injections intramuscularly,. thrice daily and on consecutive days. In the London School of Tropical Medicine and Hygiene they condemn most emphatically intramuscular injections of quinine. They say quinine causes tissue necrosis, much of the ...
متن کاملQuinine Tolerance in Pregnancy
A European lady, aged about 30 years, had bilious vomiting on 23rd October, 1936, at about midnight. In the morning of 24th October her temperature was 99.4?F. She was sick off and on, and could not retain anything. Previous history.?She went out for a picnic on 23rd October, 1936, in the morning in a forest near a river. AVhen she came back in the evening she did not feel well. At about midnig...
متن کاملEstrogen Tolerance in Pregnancy *
The important part played by estrogen in producing endometrial and myometrial modifications necessary for the implantation and retention of the embryo is perhaps better understood than is the estrogen story later in pregnancy. The growth-promoting and vascularizing effect of this hormone upon the uterus is in harmony with the fact that increasing amounts of it are present in the body fluids as ...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2012
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmcibr1207279